Nikon D300 User Manual (en)

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Auto ISO Sensitivity Control
Noise is more likely at higher sensitivities.  Use the [High ISO NR] option in 
the shooting menu to reduce noise (see page 263).  When a flash is used, 
the value selected for [Minimum shutter speed] is ignored in favor of the 
option selected for Custom Setting e1 ([Flash sync speed], pg. 288). 
Foreground subjects may be underexposed in photos taken with the flash 
at slow shutter speeds, in daylight, or against a bright background. 
Choose a flash mode other than slow sync or select exposure mode 
g or h 
and choose a larger aperture.